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My Experience
In one recent close game I had a runner thrown out at home with the setting just below most agressive (S. Green, I think).  I lowered it to normal and had another runner thrown out at third.  I lowered it again to below normal and then had Johnny Damon throw out a runner at home.  Johnny Damon with his 3.5 gun threw a laser to home!!!  So, it appears that changing the setting had no effect that I could see.
KenL