Changes you make once games are in progress for the week do seem to take effect almost immediately. Last week, I was lucky enough to catch my road games while they were being played. A key player got injured in game 1, the robot set its usual insane lineup changes for game 2, but I made changes to my default lineups and they took effect in time for game 3.

PS - Considering all the havoc caused by that internet worm, I'd cut Mike a bit of slack this week.