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That happened to me last year.
Just before the playoffs, I'm at home, last 5 games, accidently put in an OF that was tired, he gets injured for 6 games and misses the first 3 playoff games.  Can't remember his name.
When you are on the road, the computer keeps tired players from the lineup, automatically doing this.  I wish we could receive some type of message before our lineup is entered that a player is tired.  Oh well, maybe in the future.