| Player | Team | AB | TB | SLG |
|---|---|---|---|---|
| Juan Soto | Syracuse | 404 | 281 | 0.696 |
| Wil Myers | Jacksonville | 522 | 331 | 0.634 |
| Mike Trout | Riverside | 585 | 364 | 0.622 |
| Manny Machado | Havana | 632 | 383 | 0.606 |
| Teoscar Hernandez | Guildford | 572 | 345 | 0.603 |
| Jose Ramirez | Albuquerque | 604 | 364 | 0.603 |
| Kyle Tucker | Havana | 504 | 294 | 0.583 |
| Marcell Ozuna | Guildford | 640 | 366 | 0.572 |
| Mike Yastrzemski | Albuquerque | 527 | 295 | 0.560 |
| A.J. Pollock | Jacksonville | 568 | 317 | 0.558 |
| Travis d'Arnaud | Orlando | 491 | 271 | 0.552 |
| Trea Turner | Sterling | 639 | 350 | 0.548 |
| Brandon Belt | Chicago | 427 | 225 | 0.527 |
| Nicholas Castellanos | Albuquerque | 505 | 265 | 0.525 |
| Tim Anderson | Malibu | 560 | 287 | 0.513 |
| Brian Anderson | Guildford | 550 | 276 | 0.502 |
| Peter Alonso | Orlando | 469 | 234 | 0.499 |
| Alex Dickerson | Riverside | 456 | 225 | 0.493 |
| Didi Gregorius | Riverside | 590 | 290 | 0.492 |
| Donovan Solano | Riverside | 550 | 262 | 0.476 |