| Player | Team | IP | ERA |
|---|---|---|---|
| Max Fried | New Jersey | 170.2 | 1.95 |
| Lucas Giolito | Las Vegas | 191 | 2.36 |
| Kenta Maeda | Kansas City | 198.1 | 2.50 |
| Dallas Keuchel | California | 193 | 2.70 |
| Dylan Bundy | St. Louis | 208 | 2.81 |
| Pablo Lopez | New York | 173.1 | 2.91 |
| Yu Darvish | Kansas City | 225.2 | 2.95 |
| Kyle Hendricks | Kansas City | 231.1 | 3.42 |
| Spencer Turnbull | California | 174.1 | 3.46 |
| Zac Gallen | California | 223 | 3.55 |
| Julio Urias | New Jersey | 168.1 | 3.58 |
| Griffin Canning | New Jersey | 174.2 | 3.66 |
| Kevin Gausman | Tampa | 173.2 | 3.68 |
| Zack Wheeler | Las Vegas | 217 | 3.94 |
| Aaron Civale | Kansas City | 165.1 | 4.08 |
| Brady Singer | New Jersey | 198.1 | 4.13 |
| Chris Bassitt | Tampa | 177.2 | 4.36 |
| Max Scherzer | California | 206.2 | 4.40 |
| Mike Fiers | New Jersey | 169.2 | 4.40 |
| Taijuan Walker | Manhattan | 160 | 4.50 |