| Player | Team | IP | ERA |
|---|---|---|---|
| Dinelson Lamet | Sterling | 211 | 1.83 |
| Zach Plesac | Sterling | 159.1 | 1.86 |
| Jacob deGrom | Sterling | 202.2 | 2.13 |
| Trevor Bauer | Havana | 198 | 2.55 |
| Shane Bieber | Jacksonville | 206 | 2.71 |
| Lance McCullers | Guildford | 173.1 | 2.96 |
| Corbin Burnes | Jacksonville | 175 | 3.24 |
| Hyun Jin Ryu | Havana | 195.2 | 3.31 |
| Aaron Nola | Sterling | 218.2 | 3.38 |
| Luis Castillo | Havana | 200.2 | 3.50 |
| Zach Davies | Albuquerque | 180.2 | 3.54 |
| Carlos Carrasco | Riverside | 194 | 3.62 |
| Sonny Gray | Malibu | 167 | 3.72 |
| Zack Greinke | Jacksonville | 208.1 | 3.76 |
| Brad Wieck | Sterling | 46.2 | 3.86 |
| Dustin May | Guildford | 168.2 | 3.90 |
| Marco Gonzales | Malibu | 204.1 | 3.92 |
| German Marquez | Malibu | 243 | 3.93 |
| Lance Lynn | Riverside | 229.2 | 3.96 |
| Gerrit Cole | Guildford | 224.2 | 4.29 |