| Player | Team | IP | ERA |
|---|---|---|---|
| Shane Bieber | Kankakee | 241.1 | 2.13 |
| Yu Darvish | Boise | 231.2 | 2.41 |
| Trevor Bauer | Ohio | 210 | 2.79 |
| Chris Bassitt | Dakota | 164.2 | 3.06 |
| Dallas Keuchel | South Iowa | 197.2 | 3.28 |
| Zach Plesac | South Iowa | 169 | 3.36 |
| Brandon Woodruff | Portland | 226.1 | 3.42 |
| Zack Greinke | Albuquerque | 188.2 | 3.67 |
| Aaron Nola | Portland | 221.1 | 3.74 |
| Kevin Gausman | Kankakee | 170 | 3.81 |
| Luis Castillo | Dakota | 212.2 | 4.06 |
| Hyun Jin Ryu | Pea Ridge | 178.2 | 4.13 |
| Zach Eflin | Herefordshire | 180 | 4.20 |
| Zac Gallen | Orlando | 221.1 | 4.31 |
| Jose Berrios | Ohio | 192.1 | 4.40 |
| Antonio Senzatela | Pea Ridge | 204.2 | 4.66 |
| Lance Lynn | Pea Ridge | 239 | 4.74 |
| Tyler Anderson | South Iowa | 186.1 | 4.93 |
| Andrew Heaney | Boise | 196 | 5.10 |
| Justus Sheffield | South Iowa | 175.2 | 5.38 |