| Player | Team | IP | ERA |
|---|---|---|---|
| Dinelson Lamet | Fraser | 207.1 | 2.17 |
| Kenta Maeda | Fraser | 196 | 2.43 |
| Zach Davies | Kansas City | 200 | 2.70 |
| Lance McCullers | Arizona | 162.1 | 3.10 |
| Jacob deGrom | Arizona | 212.2 | 3.13 |
| Lucas Giolito | Chicago | 217 | 3.28 |
| Carlos Carrasco | Foscoe | 196.1 | 3.39 |
| Dylan Bundy | Kansas City | 203 | 3.50 |
| Brad Wieck | Fraser | 39.1 | 3.66 |
| Adam Wainwright | Montana | 200.1 | 3.73 |
| Marco Gonzales | Foscoe | 211.2 | 3.83 |
| Spencer Turnbull | Brooklyn | 172 | 3.87 |
| Pablo Lopez | Colorado | 171.1 | 3.89 |
| Julio Urias | Brooklyn | 166.1 | 3.90 |
| Framber Valdez | Foscoe | 209.2 | 3.99 |
| German Marquez | Brooklyn | 211 | 4.22 |
| Clayton Kershaw | Brooklyn | 179 | 4.22 |
| Kyle Hendricks | Arizona | 235.1 | 4.28 |
| Brady Singer | Kansas City | 200 | 4.37 |
| Gerrit Cole | Tacoma | 228.2 | 4.76 |