| Player | Team | IP | ERA |
|---|---|---|---|
| Kenta Maeda | Kansas City | 198.1 | 2.50 |
| Pablo Lopez | New York | 173.1 | 2.91 |
| Yu Darvish | Kansas City | 225.2 | 2.95 |
| Kyle Hendricks | Kansas City | 231.1 | 3.42 |
| Aaron Civale | Kansas City | 165.1 | 4.08 |
| Taijuan Walker | Manhattan | 160 | 4.50 |
| Frankie Montas | Gallup | 203.1 | 4.69 |
| Martin Perez | Kansas City | 173.2 | 4.77 |
| Logan Webb | Gallup | 178.2 | 5.09 |
| Chris Paddack | Gallup | 166.2 | 5.18 |
| Rick Porcello | New York | 216.1 | 5.99 |
| Trevor Rogers | New York | 167 | 7.33 |
| Anibal Sanchez | New York | 169.1 | 7.33 |
| Kyle Freeland | Gallup | 207 | 7.70 |