| Player | Team | RBI |
|---|---|---|
| Fernando Tatis Jr | Ohio | 155 |
| Mike Trout | Albuquerque | 147 |
| Nelson Cruz | Albuquerque | 132 |
| Marcell Ozuna | Orlando | 124 |
| Peter Alonso | Pea Ridge | 107 |
| Robinson Cano | Boise | 107 |
| Luis Robert | South Iowa | 106 |
| Trea Turner | South Iowa | 105 |
| Alex Dickerson | Boise | 104 |
| Jose Abreu | Orlando | 104 |
| Paul Goldschmidt | Pea Ridge | 98 |
| Bryce Harper | Albuquerque | 98 |
| George Springer | Kankakee | 97 |
| Dansby Swanson | Boise | 96 |
| Tim Anderson | Dakota | 94 |
| Xander Bogaerts | Kankakee | 94 |
| DJ LeMahieu | Kankakee | 94 |
| Eric Hosmer | Portland | 93 |
| Matt Olson | Ohio | 90 |
| Kole Calhoun | Boise | 90 |