| Player | Team | HR |
|---|---|---|
| Teoscar Hernandez | Guildford | 56 |
| Mike Trout | Riverside | 51 |
| Manny Machado | Havana | 50 |
| Jose Ramirez | Albuquerque | 50 |
| A.J. Pollock | Jacksonville | 48 |
| Marcell Ozuna | Guildford | 45 |
| Wil Myers | Jacksonville | 41 |
| Brian Anderson | Guildford | 38 |
| Nicholas Castellanos | Albuquerque | 37 |
| Peter Alonso | Orlando | 35 |
| Max Muncy | Syracuse | 35 |
| Juan Soto | Syracuse | 35 |
| Travis d'Arnaud | Orlando | 33 |
| Christian Yelich | Jacksonville | 31 |
| Rafael Devers | Malibu | 30 |
| Joey Votto | Riverside | 30 |
| Didi Gregorius | Riverside | 30 |
| Mike Yastrzemski | Albuquerque | 29 |
| Christian Walker | Orlando | 29 |
| Edward Olivares | Syracuse | 29 |