| Player | Team | RBI |
|---|---|---|
| Fernando Tatis Jr | Ohio | 155 |
| Mike Trout | Albuquerque | 147 |
| Nelson Cruz | Albuquerque | 132 |
| Marcell Ozuna | Orlando | 124 |
| Luis Robert | South Iowa | 106 |
| Trea Turner | South Iowa | 105 |
| Jose Abreu | Orlando | 104 |
| Bryce Harper | Albuquerque | 98 |
| George Springer | Kankakee | 97 |
| Xander Bogaerts | Kankakee | 94 |
| DJ LeMahieu | Kankakee | 94 |
| Matt Olson | Ohio | 90 |
| Max Kepler | Ohio | 88 |
| J.D. Martinez | Kankakee | 86 |
| Jeimer Candelario | Kankakee | 86 |
| Brandon Belt | Albuquerque | 85 |
| Kyle Tucker | Ohio | 84 |
| Christian Walker | Ohio | 79 |
| Jackie Bradley | South Iowa | 76 |
| Joey Votto | Kankakee | 75 |