| Player | Team | HR |
|---|---|---|
| Fernando Tatis Jr | Ohio | 60 |
| Mike Trout | Albuquerque | 58 |
| Nelson Cruz | Albuquerque | 50 |
| Marcell Ozuna | Orlando | 49 |
| Joey Votto | Kankakee | 40 |
| Bryce Harper | Albuquerque | 39 |
| George Springer | Kankakee | 38 |
| Xander Bogaerts | Kankakee | 36 |
| Matt Olson | Ohio | 36 |
| DJ LeMahieu | Kankakee | 35 |
| Rougned Odor | Ohio | 34 |
| Brandon Belt | Albuquerque | 34 |
| Jose Abreu | Orlando | 32 |
| Max Kepler | Ohio | 32 |
| Brian Anderson | Ohio | 31 |
| J.D. Martinez | Kankakee | 29 |
| Christian Walker | Ohio | 28 |
| Cody Bellinger | Orlando | 27 |
| Trea Turner | South Iowa | 27 |
| Jackie Bradley | South Iowa | 27 |