| Player | Team | SO |
|---|---|---|
| Luis Robert | South Iowa | 235 |
| Yoan Moncada | Portland | 223 |
| Dansby Swanson | Boise | 223 |
| Matt Olson | Ohio | 210 |
| Peter Alonso | Pea Ridge | 209 |
| Teoscar Hernandez | Herefordshire | 201 |
| Renato Nunez | Herefordshire | 198 |
| Cavan Biggio | Dakota | 197 |
| Jose Abreu | Orlando | 188 |
| Jeff Mathis | Kankakee | 185 |
| Hunter Dozier | Kankakee | 182 |
| Jeimer Candelario | Kankakee | 182 |
| J.D. Martinez | Kankakee | 181 |
| Marcell Ozuna | Orlando | 181 |
| Nelson Cruz | Albuquerque | 180 |
| Ramon Laureano | Portland | 180 |
| Fernando Tatis Jr | Ohio | 179 |
| Rougned Odor | Ohio | 178 |
| Brian Anderson | Ohio | 171 |
| Mark Canha | Pea Ridge | 171 |