| Player | Team | RBI |
|---|---|---|
| Manny Machado | Brooklyn | 167 |
| Luke Voit | Kansas City | 132 |
| Lourdes Gurriel Jr. | Montana | 122 |
| Eloy Jimenez | Brooklyn | 118 |
| Trevor Story | Montana | 116 |
| Jose Ramirez | Foscoe | 115 |
| Dominic Smith | Montana | 113 |
| Anthony Rizzo | Colorado | 107 |
| Juan Soto | Brooklyn | 103 |
| Didi Gregorius | Arizona | 103 |
| Travis d'Arnaud | Colorado | 103 |
| Robbie Grossman | Colorado | 101 |
| Ronald Acuna | Fraser | 100 |
| Michael Conforto | Southland | 100 |
| Mookie Betts | Kansas City | 99 |
| Freddie Freeman | Foscoe | 94 |
| Wilmer Flores | Southland | 92 |
| Evan Longoria | Southland | 91 |
| Francisco Lindor | Brooklyn | 90 |
| A.J. Pollock | Fraser | 87 |