| Player | Team | SO |
|---|---|---|
| Willy Adames | Chicago | 251 |
| Franmil Reyes | Southland | 239 |
| Javier Baez | Foscoe | 227 |
| Garrett Hampson | Montana | 224 |
| Matt Carpenter | Tacoma | 219 |
| Christian Yelich | Arizona | 214 |
| Ian Happ | Chicago | 210 |
| Eugenio Suarez | Arizona | 208 |
| Aristides Aquino | Tacoma | 204 |
| Brandon Lowe | Kansas City | 204 |
| Trevor Story | Montana | 198 |
| Mike Yastrzemski | Colorado | 194 |
| Trent Grisham | Montana | 192 |
| Kyle Schwarber | Chicago | 189 |
| Eloy Jimenez | Brooklyn | 186 |
| Jorge Soler | Fraser | 185 |
| Ronald Acuna | Fraser | 185 |
| Austin Meadows | Foscoe | 184 |
| Josh Bell | Brooklyn | 181 |
| Michael Conforto | Southland | 180 |