| Player | Team | HR |
|---|---|---|
| Luke Voit | Kansas City | 61 |
| Manny Machado | Brooklyn | 53 |
| Wilmer Flores | Southland | 45 |
| Trevor Story | Montana | 42 |
| Evan Longoria | Southland | 40 |
| Jose Ramirez | Foscoe | 40 |
| Freddie Freeman | Foscoe | 39 |
| Ronald Acuna | Fraser | 39 |
| Anthony Rizzo | Colorado | 38 |
| Salvador Perez | Foscoe | 37 |
| Eloy Jimenez | Brooklyn | 37 |
| Travis d'Arnaud | Colorado | 37 |
| Juan Soto | Brooklyn | 36 |
| Eddie Rosario | Chicago | 36 |
| Christian Yelich | Arizona | 35 |
| Corey Seager | Foscoe | 35 |
| Mookie Betts | Kansas City | 35 |
| Michael Conforto | Southland | 34 |
| Lourdes Gurriel Jr. | Montana | 33 |
| Jesse Winker | Fraser | 33 |