| Player | Team | SO |
|---|---|---|
| Luis Robert | South Iowa | 235 |
| Matt Olson | Ohio | 210 |
| Jose Abreu | Orlando | 188 |
| Jeff Mathis | Kankakee | 185 |
| Hunter Dozier | Kankakee | 182 |
| Jeimer Candelario | Kankakee | 182 |
| J.D. Martinez | Kankakee | 181 |
| Marcell Ozuna | Orlando | 181 |
| Nelson Cruz | Albuquerque | 180 |
| Fernando Tatis Jr | Ohio | 179 |
| Rougned Odor | Ohio | 178 |
| Brian Anderson | Ohio | 171 |
| Miguel Sano | Orlando | 167 |
| Mike Zunino | Albuquerque | 159 |
| Jackie Bradley | South Iowa | 158 |
| Randal Grichuk | South Iowa | 156 |
| J.D. Davis | South Iowa | 154 |
| Travis Shaw | Albuquerque | 153 |
| Mike Trout | Albuquerque | 150 |
| Xander Bogaerts | Kankakee | 150 |