| Player | Team | HR |
|---|---|---|
| Blake Snell | Orlando | 57 |
| Jake Odorizzi | Herefordshire | 55 |
| Jordan Lyles | Kankakee | 50 |
| Lance Lynn | Pea Ridge | 49 |
| Wade Leblanc | South Iowa | 44 |
| Matt Shoemaker | Albuquerque | 44 |
| Andrew Heaney | Boise | 43 |
| Trevor Rogers | Herefordshire | 43 |
| Brandon Woodruff | Portland | 42 |
| Justin Dunn | Boise | 41 |
| Dylan Cease | Ohio | 41 |
| Asher Wojciechowski | Dakota | 40 |
| James Paxton | Ohio | 39 |
| Tanner Roark | Herefordshire | 39 |
| Aaron Nola | Portland | 38 |
| Anibal Sanchez | Kankakee | 38 |
| Mike Fiers | Dakota | 37 |
| Antonio Senzatela | Pea Ridge | 36 |
| Zach Eflin | Herefordshire | 35 |
| Zac Gallen | Orlando | 35 |