| Player | Team | HR |
|---|---|---|
| Masahiro Tanaka | Las Vegas | 55 |
| Matthew Boyd | Gallup | 52 |
| Jordan Lyles | St. Louis | 47 |
| Jonathan Stiever | St. Louis | 42 |
| Chris Paddack | Gallup | 42 |
| Anibal Sanchez | New York | 42 |
| Zack Godley | New York | 41 |
| John Means | New Jersey | 40 |
| J.A. Happ | Manhattan | 39 |
| Trevor Rogers | New York | 37 |
| Alex Cobb | Boston | 37 |
| Zac Gallen | California | 36 |
| Kyle Freeland | Gallup | 35 |
| Kyle Hendricks | Kansas City | 35 |
| Wade Leblanc | Boston | 34 |
| Taijuan Walker | Manhattan | 34 |
| Frankie Montas | Gallup | 34 |
| Max Scherzer | California | 34 |
| Kenta Maeda | Kansas City | 33 |
| Jesus Luzardo | Las Vegas | 33 |