| Player | Team | L |
|---|---|---|
| Kyle Freeland | Gallup | 20 |
| Anibal Sanchez | New York | 19 |
| Zack Godley | New York | 19 |
| Jordan Lyles | St. Louis | 19 |
| Rick Porcello | New York | 17 |
| Frankie Montas | Gallup | 16 |
| Trevor Rogers | New York | 15 |
| Chris Paddack | Gallup | 15 |
| Max Scherzer | California | 13 |
| Logan Webb | Gallup | 13 |
| Matthew Boyd | Gallup | 13 |
| J.A. Happ | Manhattan | 13 |
| Wade Leblanc | Boston | 13 |
| Kyle Hendricks | Kansas City | 12 |
| Yu Darvish | Kansas City | 12 |
| Jordan Montgomery | Manhattan | 12 |
| Dakota Hudson | St. Louis | 12 |
| Danny Duffy | St. Louis | 12 |
| Spencer Turnbull | California | 12 |
| Ryan Yarbrough | Tampa | 11 |