| Player | Team | HR |
|---|---|---|
| Gerrit Cole | Tacoma | 68 |
| Jon Lester | Southland | 45 |
| Dustin May | Arizona | 44 |
| Trevor Williams | Chicago | 44 |
| Kyle Gibson | Montana | 44 |
| Martin Perez | Chicago | 42 |
| Anthony DeSclafani | Tacoma | 42 |
| Austin Voth | Montana | 42 |
| Chad Kuhl | Southland | 39 |
| Marco Gonzales | Foscoe | 38 |
| Ross Stripling | Montana | 38 |
| Kenta Maeda | Fraser | 38 |
| Brady Singer | Kansas City | 37 |
| Mike Minor | Southland | 37 |
| Kyle Hendricks | Arizona | 37 |
| Clayton Kershaw | Brooklyn | 37 |
| Michael Wacha | Tacoma | 36 |
| Aaron Civale | Tacoma | 36 |
| Jake Woodford | Chicago | 36 |
| Adam Wainwright | Montana | 36 |