| Player | Team | HR |
|---|---|---|
| Gerrit Cole | Guildford | 56 |
| Ryan Castellani | Chicago | 48 |
| Lance Lynn | Riverside | 47 |
| Asher Wojciechowski | Chicago | 45 |
| Blake Snell | Guildford | 41 |
| Andrew Heaney | Syracuse | 39 |
| Dylan Cease | Havana | 39 |
| Brandon Woodruff | Malibu | 38 |
| Patrick Corbin | Orlando | 37 |
| Reynaldo Lopez | Syracuse | 37 |
| Nathan Eovaldi | Syracuse | 36 |
| Aaron Nola | Sterling | 36 |
| Antonio Senzatela | Jacksonville | 36 |
| Tyler Glasnow | Havana | 33 |
| Marco Gonzales | Malibu | 32 |
| Ljay Newsome | Syracuse | 32 |
| Matt Shoemaker | Orlando | 32 |
| Ross Stripling | Chicago | 31 |
| Kris Bubic | Orlando | 30 |
| Trevor Bauer | Havana | 30 |