| Player | Team | L |
|---|---|---|
| Patrick Corbin | Orlando | 21 |
| Kris Bubic | Orlando | 16 |
| Tyler Anderson | Orlando | 15 |
| Jake Arrieta | Albuquerque | 15 |
| Nick Margevicius | Chicago | 14 |
| Framber Valdez | Albuquerque | 14 |
| Brandon Woodruff | Malibu | 13 |
| Antonio Senzatela | Jacksonville | 13 |
| Jose Berrios | Riverside | 13 |
| Dylan Cease | Havana | 13 |
| Adrian Houser | Orlando | 12 |
| Andrew Heaney | Syracuse | 12 |
| Jonathan Brubaker | Albuquerque | 12 |
| Asher Wojciechowski | Chicago | 12 |
| Hyun Jin Ryu | Havana | 11 |
| Gerrit Cole | Guildford | 11 |
| Tyler Glasnow | Havana | 10 |
| Lance Lynn | Riverside | 10 |
| Ryan Castellani | Chicago | 10 |
| Tommy Milone | Malibu | 10 |