| Player | Team | HR |
|---|---|---|
| Blake Snell | Orlando | 57 |
| Jordan Lyles | Kankakee | 50 |
| Wade Leblanc | South Iowa | 44 |
| Matt Shoemaker | Albuquerque | 44 |
| Dylan Cease | Ohio | 41 |
| James Paxton | Ohio | 39 |
| Anibal Sanchez | Kankakee | 38 |
| Zac Gallen | Orlando | 35 |
| Griffin Canning | Orlando | 35 |
| Zach Plesac | South Iowa | 31 |
| Tommy Milone | Ohio | 30 |
| Trevor Bauer | Ohio | 29 |
| Brett Anderson | Orlando | 28 |
| Jorge Lopez | Orlando | 26 |
| Deivi Garcia | Ohio | 26 |
| Cristian Javier | Orlando | 25 |
| Shane Bieber | Kankakee | 25 |
| Jose Berrios | Ohio | 24 |
| Kris Bubic | Orlando | 24 |
| Kevin Gausman | Kankakee | 23 |