| Player | Team | HR |
|---|---|---|
| Matthew Boyd | Gallup | 52 |
| Chris Paddack | Gallup | 42 |
| Anibal Sanchez | New York | 42 |
| Zack Godley | New York | 41 |
| J.A. Happ | Manhattan | 39 |
| Trevor Rogers | New York | 37 |
| Alex Cobb | Boston | 37 |
| Kyle Freeland | Gallup | 35 |
| Kyle Hendricks | Kansas City | 35 |
| Wade Leblanc | Boston | 34 |
| Taijuan Walker | Manhattan | 34 |
| Frankie Montas | Gallup | 34 |
| Kenta Maeda | Kansas City | 33 |
| Michael Wacha | Boston | 28 |
| Rick Porcello | New York | 26 |
| Justin Dunn | Manhattan | 25 |
| Patrick Sandoval | Boston | 25 |
| Chad Green | Manhattan | 24 |
| Jordan Montgomery | Manhattan | 24 |
| Aaron Civale | Kansas City | 23 |