| Player | Team | R |
|---|---|---|
| Anibal Sanchez | Wisc. Rapids | 167 |
| Frankie Montas | Wisc. Rapids | 161 |
| Braxton Garrett | Oak Lawn | 150 |
| Kyle Freeland | Monet | 147 |
| Aaron Civale | El Paso | 130 |
| Antonio Senzatela | El Paso | 126 |
| Patrick Corbin | Brooklyn | 118 |
| Kris Bubic | Monet | 118 |
| Zack Greinke | Wisc. Rapids | 117 |
| Zack Wheeler | Brooklyn | 115 |
| Madison Bumgarner | El Paso | 115 |
| Randy Dobnak | Oak Lawn | 114 |
| Dylan Cease | Dayton | 113 |
| Alec Mills | Monet | 111 |
| Ryan Yarbrough | El Paso | 110 |
| Nathan Eovaldi | El Paso | 110 |
| Martin Perez | Chicago | 109 |
| John Means | El Paso | 105 |
| Mike Fiers | Chicago | 104 |
| Lance Lynn | Brooklyn | 102 |