| Player | Team | R |
|---|---|---|
| Austin Voth | Burlington | 151 |
| German Marquez | Clinton | 148 |
| Trevor Williams | Amarillo | 148 |
| Logan Webb | Amarillo | 148 |
| Kyle Gibson | Detroit | 144 |
| Ryan Castellani | Burlington | 139 |
| Aaron Nola | Burlington | 132 |
| Tanner Roark | Detroit | 131 |
| Seth Lugo | Amarillo | 131 |
| Asher Wojciechowski | Phoenix | 126 |
| Rick Porcello | Phoenix | 124 |
| Jake Odorizzi | Amarillo | 122 |
| Mike Minor | Connecticut | 120 |
| Carlos Martinez | Huntington Beach | 118 |
| Daulton Jefferies | Huntington Beach | 102 |
| Max Scherzer | Clinton | 101 |
| Gerrit Cole | Burlington | 98 |
| Kyle Hendricks | Connecticut | 96 |
| Wade Leblanc | Clinton | 95 |
| Chris Paddack | Huntington Beach | 93 |