| Player | Team | R |
|---|---|---|
| Anibal Sanchez | Wisc. Rapids | 167 |
| Frankie Montas | Wisc. Rapids | 161 |
| Aaron Civale | El Paso | 130 |
| Antonio Senzatela | El Paso | 126 |
| Zack Greinke | Wisc. Rapids | 117 |
| Madison Bumgarner | El Paso | 115 |
| Ryan Yarbrough | El Paso | 110 |
| Nathan Eovaldi | El Paso | 110 |
| Martin Perez | Chicago | 109 |
| John Means | El Paso | 105 |
| Mike Fiers | Chicago | 104 |
| Chi Chi Gonzalez | Chicago | 96 |
| Zach Eflin | Chicago | 96 |
| Adrian Houser | Chicago | 95 |
| Chris Bassitt | Chicago | 94 |
| Hyun Jin Ryu | Wisc. Rapids | 90 |
| Johnny Cueto | Milwaukee | 85 |
| Trevor Bauer | Peculiar | 77 |
| Alex Cobb | Milwaukee | 76 |
| Reynaldo Lopez | Wisc. Rapids | 75 |